Hepatocyte Growth Factor is a Potential Lymphangiogenic Factor; Clinical Implications

Title: Hepatocyte Growth Factor is a Potential Lymphangiogenic Factor; Clinical Implications

Volume: 6 Issue: 2

Author(s): Wen G. Jiang and Andrew J. Sanders

Affiliation:

Keywords: Hepatocyte growth factor, lymphangiogenesis, endothelial cells, VEGF, melanoma, cMET, lymph node metastases, prostate cancer, lymphatic invasion, metastasis, squamous cell carcinoma, lymphatic microvessel density, LYVE-1, Prox-1, VEGF-R3, breast cancer, HGF antagonist, in vivo tumour models, D2-40 antibody, MW 40K, ERK, akt, PECAM

Abstract: Hepatocyte growth factor (HGF) is a known angiogenic factor that has profound effects on vascular endothelial cells. In recent years, it has been reported that the factor also acts as a lymphagiogenic factor that induces lymphangenesis from lymphatic endothelial cells. The current article debates some of the recent evidence showing such an effect and also discusses the clinical studies that link to lymphatic related conditions, together with clinical implications.

Cite this article as:

G. Jiang Wen and J. Sanders Andrew, Hepatocyte Growth Factor is a Potential Lymphangiogenic Factor; Clinical Implications, Current Signal Transduction Therapy 2011; 6 (2) . https://dx.doi.org/10.2174/157436211795659900