Postprandial Lipemia in Children and Adolescents

Genovefa      D. Kolovou; Helen      Bilianou; Dimitri      P. Mikhailidis

doi:10.2174/157016111795495521

Abstract

Atherosclerosis is a result of a lifelong process that has its origins in childhood. Data in adults suggest that impaired postprandial lipoprotein metabolism may contribute to, or be a marker of, the development and progression of atherosclerosis. After an 8-year follow up period, the Bogalusa Heart Study showed that children with low high density lipoprotein cholesterol, high triglyceride levels and high body mass index had a notably increased occurrence of dyslipidemia as adults. A significantly greater postprandial response of triglycerides in children with elevated fasting triglyceride levels was reported. It is well known that dietary fat is associated with higher plasma triglyceride levels. It is not clear if postprandial lipemia should be evaluated in children and adolescents. However, in special situations this may help determine the underlying lipid disorder. This review discusses the current status in this field.

Keywords: Adolescent, children, dyslipidemia, postprandial lipaemia, triglyceride, low high density lipoprotein, obesity, hypertension, hypertriglyceridaemia, diabetes mellitus