A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides

Haitao      Yang; Zhiwei      Miao; Ruyu      Chen

doi:10.2174/157017811795684974

Abstract

A copper-catalyzed coupling reaction of aryl halides with various aromatic cyclic secondary amines in DMSO has been developed efficiently. The versatile and efficient copper catalyst system is of wide-spread and practical application in cross-coupling reactions.

Keywords: N-Arylation, Aromatic cyclic secondary amines, Copper catalyst, Cross-coupling, pharmaceutical, heterocycle, dioxane, toluene, dichloroethane, aryl halide

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Letters in Organic Chemistry

Title: A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides

Volume: 8 Issue: 5

Author(s): Haitao Yang, Zhiwei Miao and Ruyu Chen

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Keywords: N-Arylation, Aromatic cyclic secondary amines, Copper catalyst, Cross-coupling, pharmaceutical, heterocycle, dioxane, toluene, dichloroethane, aryl halide

Abstract: A copper-catalyzed coupling reaction of aryl halides with various aromatic cyclic secondary amines in DMSO has been developed efficiently. The versatile and efficient copper catalyst system is of wide-spread and practical application in cross-coupling reactions.

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Yang Haitao, Miao Zhiwei and Chen Ruyu, A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides, Letters in Organic Chemistry 2011; 8 (5) . https://dx.doi.org/10.2174/157017811795684974