Facile Catalyst-Free Allylation of Isatins Under Mild Conditions in Dimethylformamide

Title: Facile Catalyst-Free Allylation of Isatins Under Mild Conditions in Dimethylformamide

Volume: 8 Issue: 5

Author(s): Li-Na Jia, Lin Peng, Liang-Liang Wang, Jian-Fei Bai, Ji-Ya Fu, Qing-Chun Huang, Fei-Ying Wang, Xiao-Ying Xu and Li-Xin Wang*

Affiliation:

• Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041,China

Keywords: Allylation, isatin, allyltrichlorosilane, 3-allyl-3-hydroxy-2-oxindoles, catalyst-free, hydroxyglucoisatisins, convulutamydines, donaxaridines, HIV protease inhibitor, welwitindoline

Abstract: The catalyst-free allylation of isatins with allyltrichlorosilane was performed smoothly in DMF under mild conditions and moderate to excellent yields (60%-94%) were obtained. This protocol provided a new and efficient approach for the preparation of 3-allyl-3-hydroxy-2-oxindoles.

Cite this article as:

Jia Li-Na, Peng Lin, Wang Liang-Liang, Bai Jian-Fei, Fu Ji-Ya, Huang Qing-Chun, Wang Fei-Ying, Xu Xiao-Ying and Wang Li-Xin*, Facile Catalyst-Free Allylation of Isatins Under Mild Conditions in Dimethylformamide, Letters in Organic Chemistry 2011; 8 (5) . https://dx.doi.org/10.2174/157017811795685072