Stem Cells in Brain Tumorigenesis and their Impact on Therapy

Title: Stem Cells in Brain Tumorigenesis and their Impact on Therapy

Volume: 6 Issue: 4

Author(s): Andres Felipe Cardona, Carmen Balana, Diana Torres, Henry Becerra, Leon Dario Ortiz and Camilo E. Fadul

Affiliation:

Keywords: Brain tumor, glioma, stem cells, tumorigenesis, neurogenesis, development, genetics, molecular biology, central nervous system neoplasms, medulloblastoma

Abstract: The concept that the genesis of new cells in the adult mammalian brain is negligible has long influenced our perception and understanding of the origin and development of central nervous system (CNS) tumors. The discovery that neurons and glia are produced throughout life from neural stem cells provides new possibilities for candidate precursor cells of CNS neoplasms. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis. As such, opportunities become available to identify new therapeutic strategies.

Cite this article as:

Felipe Cardona Andres, Balana Carmen, Torres Diana, Becerra Henry, Dario Ortiz Leon and E. Fadul Camilo, Stem Cells in Brain Tumorigenesis and their Impact on Therapy, Current Stem Cell Research & Therapy 2011; 6 (4) . https://dx.doi.org/10.2174/157488811797904317