Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds

Elena      Valverde; Eva      Torres; Salvador      Guardiola; Lieve      Naesens; Santiago      Vazquez

doi:10.2174/157340611794859299

Abstract

The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.

Keywords: Antiviral activity, bisnoradamantanes, polycyclic compounds, sulfites, sulfur monoxide, vesicular stomatitis virus, 1,2-diols, thionyl chloride, adamantane, ring-contracted analogs, memantine, rimantadine

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Medicinal Chemistry

Title: Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds

Volume: 7 Issue: 2

Author(s): Elena Valverde, Eva Torres, Salvador Guardiola, Lieve Naesens and Santiago Vazquez

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Abstract: The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.

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Valverde Elena, Torres Eva, Guardiola Salvador, Naesens Lieve and Vazquez Santiago, Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds, Medicinal Chemistry 2011; 7 (2) . https://dx.doi.org/10.2174/157340611794859299