Erbin, a Negative Regulator in Diverse Signal Pathways

Title: Erbin, a Negative Regulator in Diverse Signal Pathways

Volume: 11 Issue: 8

Author(s): Dan Liu, Ming Shi, Huijun Duan, Caili Han and Ning Guo

Affiliation:

Keywords: Erbin, MAPK, ERK, NF-κB, TGF-β, signal transduction, carbonyl termini, epithelial morphogensis, mutagenesis, velocardiofacial syndrome, down regulation

Abstract: Erbin belongs to the LAP protein family. Originally, Erbin was described as a Her2-interacting protein. Recent studies demonstrated that Erbin could inhibit the Ras-mediated activation of the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and transforming growth factor β (TGF-β) signaling pathways. It suggests that Erbin may function as a signaling molecule. The functions of Erbin in determining cell polarity and cell adhesion have been well described. This review mainly focuses on the recent findings in regulation of signaling pathways by Erbin.

Cite this article as:

Liu Dan, Shi Ming, Duan Huijun, Han Caili and Guo Ning, Erbin, a Negative Regulator in Diverse Signal Pathways, Current Protein & Peptide Science 2010; 11 (8) . https://dx.doi.org/10.2174/138920310794557673