A Differential Scanning Calorimetry Study of the Effects and Interactions of Antimicrobial Peptide LS3 on Phosphatidylethanolamine Bilayers

Farid      Sa'adedin; Jeremy      P. Bradshaw

doi:10.2174/0929866511009011345

Abstract

Differential Scanning Calorimetry studies of a synthetic peptide revealed the peptide decreased the temperature of the lamellar-hexagonal phase transition of cis-trans mixtures of phosphatidylethanolamine. The transition enthalpy varied significantly with lipid composition. The findings are discussed with reference to peptide saturation on the bilayer surface, bilayer thinning and peptide orientation.

Keywords: Antimicrobial peptide, amphipathic helix, DSC, LS3, phosphatidylethanolamine, phase transition, Antimicrobial, amphipathic, phase, (LSSLLSL)3, bilayer, (DSC), crystallography, DOPE, (MLVs), EDTA, TH, PE bilayers, DPOPE

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Protein & Peptide Letters

Title: A Differential Scanning Calorimetry Study of the Effects and Interactions of Antimicrobial Peptide LS3 on Phosphatidylethanolamine Bilayers

Volume: 17 Issue: 11

Author(s): Farid Sa'adedin and Jeremy P. Bradshaw

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Abstract: Differential Scanning Calorimetry studies of a synthetic peptide revealed the peptide decreased the temperature of the lamellar-hexagonal phase transition of cis-trans mixtures of phosphatidylethanolamine. The transition enthalpy varied significantly with lipid composition. The findings are discussed with reference to peptide saturation on the bilayer surface, bilayer thinning and peptide orientation.

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Sa'adedin Farid and P. Bradshaw Jeremy, A Differential Scanning Calorimetry Study of the Effects and Interactions of Antimicrobial Peptide LS3 on Phosphatidylethanolamine Bilayers, Protein & Peptide Letters 2010; 17 (11) . https://dx.doi.org/10.2174/0929866511009011345