Small Molecule Antagonists of the Chemokine Receptor CCR5

Title: Small Molecule Antagonists of the Chemokine Receptor CCR5

Volume: 10 Issue: 13

Author(s): Remy C. Lemoine and Jutta Wanner

Affiliation:

Keywords: CCR5, HIV-1/AIDS, inflammatory diseases, medicinal chemistry, clinical trials, antagonists

Abstract: This review will focus on the discovery and clinical development of small molecule antagonists of CCR5 for the treatment of HIV-1/AIDS, as well as for the potential treatment of inflammatory diseases. In particular, we will focus on the specific medicinal chemistry problems that were faced during the discovery of the molecules. We will also describe limited data from clinical development phases focusing on specific issues that arose during the clinical trials. Finally, we will touch on the mechanism of action of CCR5 antagonists.

Cite this article as:

C. Lemoine Remy and Wanner Jutta, Small Molecule Antagonists of the Chemokine Receptor CCR5, Current Topics in Medicinal Chemistry 2010; 10 (13) . https://dx.doi.org/10.2174/156802610791561219