Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences

Title: Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences

Volume: 10 Issue: 7

Author(s): Teresa Gonzalez, Miren David, Cristina Moreno, Alvaro Macias and Carmen Valenzuela

Affiliation:

Keywords: Ion channels, Kv channels, Beta subunits, Kvβ1.3, Kv1.5, Bupivacaine

Abstract: Kv1.5 channels are homotetramers of α-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kvβ1.3 assemblies with Kvα1.5 and modifies its gating and pharmacology. A further knowledge of α-β interactions and pharmacology will lead a better design of new drugs.

Cite this article as:

Gonzalez Teresa, David Miren, Moreno Cristina, Macias Alvaro and Valenzuela Carmen, Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences, Mini-Reviews in Medicinal Chemistry 2010; 10 (7) . https://dx.doi.org/10.2174/138955710791384018