Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage

Title: Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage

Volume: 10 Issue: 7

Author(s): M.G. Repetto and A. Boveris

Affiliation:

Keywords: Cytoprotection, dehydroleucodine, ethanol gastric damage, gastric ulcer, inflammation, sesquiterpene lactone

Abstract: Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.

Cite this article as:

Repetto M.G. and Boveris A., Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage, Mini-Reviews in Medicinal Chemistry 2010; 10 (7) . https://dx.doi.org/10.2174/138955710791383992