A New Method of Reducing 2-Mercapto-Substituted 1,3,4-Oxadizoles: Synthesis of Acylhydrazine Derivatives

Muhammad      Zareef; Rashid      Iqbal; Javid      Hussain Zaidi; Muhammad      Arfan; Muhammad      Ali; Khalid      M. Khan

doi:10.2174/157017810791514670

Abstract

A new method has been developed for the synthesis of acylhydrazines 5a-g by the reduction of unsymmetrical 1,3,4-oxadiazoles 4a-g by using sodium borohydride/acetic acid combination. Later on, acylhydrazines 5a-g were converted to their corresponding sulfonamide derivatives 6a-d.

Keywords: Acylhydrazine derivatives, benzenediazasulfonamide, 1,3,4-oxadiazole, sodium acytoxyborohydride

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Letters in Organic Chemistry

Title: A New Method of Reducing 2-Mercapto-Substituted 1,3,4-Oxadizoles: Synthesis of Acylhydrazine Derivatives

Volume: 7 Issue: 5

Author(s): Muhammad Zareef, Rashid Iqbal, Javid Hussain Zaidi, Muhammad Arfan, Muhammad Ali and Khalid M. Khan

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Keywords: Acylhydrazine derivatives, benzenediazasulfonamide, 1,3,4-oxadiazole, sodium acytoxyborohydride

Abstract: A new method has been developed for the synthesis of acylhydrazines 5a-g by the reduction of unsymmetrical 1,3,4-oxadiazoles 4a-g by using sodium borohydride/acetic acid combination. Later on, acylhydrazines 5a-g were converted to their corresponding sulfonamide derivatives 6a-d.

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Zareef Muhammad, Iqbal Rashid, Hussain Zaidi Javid, Arfan Muhammad, Ali Muhammad and M. Khan Khalid, A New Method of Reducing 2-Mercapto-Substituted 1,3,4-Oxadizoles: Synthesis of Acylhydrazine Derivatives, Letters in Organic Chemistry 2010; 7 (5) . https://dx.doi.org/10.2174/157017810791514670