Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones

Title: Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones

Volume: 7 Issue: 5

Author(s): Raid J. Abdel-Jalil, Ehab Al-Momani, Lubna Tahtamooni, H.-Juergen Machulla and Wolfgang Voelter

Affiliation:

Keywords: Quinazolinone derivatives, piperazine derivatives, anticancer activity

Abstract: A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4- methyl-1-thyl-1-piperazinyl)- 2-thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.

Cite this article as:

J. Abdel-Jalil Raid, Al-Momani Ehab, Tahtamooni Lubna, Machulla H.-Juergen and Voelter Wolfgang, Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones, Letters in Organic Chemistry 2010; 7 (5) . https://dx.doi.org/10.2174/157017810791514751