High-Performance Liquid Chromatography of Biologically Important, Small Epimeric Peptides and their L, D-Amino Acid Content

Title: High-Performance Liquid Chromatography of Biologically Important, Small Epimeric Peptides and their L, D-Amino Acid Content

Volume: 10 Issue: 4

Author(s): I. Ilisz, Z. Pataj, A. Aranyi and A. Peter

Affiliation:

Keywords: Chirality, enantiomers, peptide epimers, amino acids, high-performance liquid chromatography, chiral derivatizing agents (CDAs), chiral stationary phases (CSPs)

Abstract: Since most of the proteinogenic α-amino acids contain a chiral carbon atom, the stereoisomers of both these amino acids and the peptides in which they are to be found may possess differences in biological activity in living systems. The important analytical task of the separation of optical isomers is achieved mainly by chromatographic methods. This special review surveys direct and indirect HPLC separations of biologically important, small epimeric peptides and their L,D-amino acid content.

Cite this article as:

Ilisz I., Pataj Z., Aranyi A. and Peter A., High-Performance Liquid Chromatography of Biologically Important, Small Epimeric Peptides and their L, D-Amino Acid Content, Mini-Reviews in Medicinal Chemistry 2010; 10 (4) . https://dx.doi.org/10.2174/138955710791330981