Review of 5-HT4R Ligands: State of Art and Clinical Applications

Title: Review of 5-HT4R Ligands: State of Art and Clinical Applications

Volume: 10 Issue: 5

Author(s): Ronan Bureau, Michel Boulouard, Francois Dauphin, Frank Lezoualc'h and Sylvain Rault

Affiliation:

Keywords: Serotonin, 5-HT4 receptor ligands, Agonists, Antagonists, Clinical applications

Abstract: This article reviews the medicinal implications of 5-HT4R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT4R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.

Cite this article as:

Bureau Ronan, Boulouard Michel, Dauphin Francois, Lezoualc'h Frank and Rault Sylvain, Review of 5-HT4R Ligands: State of Art and Clinical Applications, Current Topics in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/156802610791111551