The First Kinetic Enzymatic Resolution of Methyl Ester of C75

Title: The First Kinetic Enzymatic Resolution of Methyl Ester of C75

Volume: 7 Issue: 3

Author(s): Kuheli Chakrabarty, Cristina Forzato, Patrizia Nitti, Giuliana Pitacco and Ennio Valentin

Affiliation:

Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I

Abstract: Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.

Cite this article as:

Chakrabarty Kuheli, Forzato Cristina, Nitti Patrizia, Pitacco Giuliana and Valentin Ennio, The First Kinetic Enzymatic Resolution of Methyl Ester of C75, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112405