Anesthesia and Postoperative Cognitive Dysfunction (POCD)

Bettina      Jungwirth; Walter      Zieglgansberger; Eberhard      Kochs; Gerhard      Rammes

doi:10.2174/138955709791012229

Abstract

POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

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Mini-Reviews in Medicinal Chemistry

Title: Anesthesia and Postoperative Cognitive Dysfunction (POCD)

Volume: 9 Issue: 14

Author(s): Bettina Jungwirth, Walter Zieglgansberger, Eberhard Kochs and Gerhard Rammes

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Abstract: POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

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Jungwirth Bettina, Zieglgansberger Walter, Kochs Eberhard and Rammes Gerhard, Anesthesia and Postoperative Cognitive Dysfunction (POCD), Mini-Reviews in Medicinal Chemistry 2009; 9 (14) . https://dx.doi.org/10.2174/138955709791012229