Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53

Title: Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53

Volume: 17 Issue: 5

Author(s): R. Ito, H. Kanno, A. Takahashi, R. Matsumoto, N. Kobayashi, T. Yoshida and T. Saito

Affiliation:

Keywords: Osteosarcoma, p53 peptide, protein transduction therapy, protein transduction domain, poly arginine, nuclear localization signal

Abstract: Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.

Cite this article as:

Ito R., Kanno H., Takahashi A., Matsumoto R., Kobayashi N., Yoshida T. and Saito T., Efficient Growth Inhibition of Human Osteosarcoma Cells Using a Peptide Derived from the MDM-2-Binding Site of p53, Protein & Peptide Letters 2010; 17 (5) . https://dx.doi.org/10.2174/092986610791112639