Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

Huiming      Huang; Dan      Chen; Shaohua      Li; Chengmei      Liu

doi:10.2174/157017810790796336

Abstract

In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

Keywords: Tartaric acid, malic acid, thiadiazole, acylation, nucleophilic substitution, matrix metalloproteinase inhibitors

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Letters in Organic Chemistry

Title: Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

Volume: 7 Issue: 2

Author(s): Huiming Huang, Dan Chen, Shaohua Li and Chengmei Liu

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Keywords: Tartaric acid, malic acid, thiadiazole, acylation, nucleophilic substitution, matrix metalloproteinase inhibitors

Abstract: In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

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Huang Huiming, Chen Dan, Li Shaohua and Liu Chengmei, Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796336