Samarium Diiodide Catalyzed Aza-Michael Reactions for the Formation of β-Amino Amides

Irena      Reboule; Sophie      Bezzenine-Lafollee; Jacqueline      Collin; Richard      Gil; Myriam      Martin

doi:10.2174/157017810790796255

Abstract

Samarium diiodide is an efficient Lewis acid type catalyst for the 1,4-addition of aromatic amines onto α,β- unsaturated N-benzoyl amides affording new β-amino amides. These reactions are compared with similar aza-Michael additions involving α,β-unsaturated-N-acyloxazolidinones.

Keywords: Samarium diiodide, catalysis, amines, Aza-Michael reaction, carbon-nitrogen bond formation

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Letters in Organic Chemistry

Title: Samarium Diiodide Catalyzed Aza-Michael Reactions for the Formation of β-Amino Amides

Volume: 7 Issue: 2

Author(s): Irena Reboule, Sophie Bezzenine-Lafollee, Jacqueline Collin, Richard Gil and Myriam Martin

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Keywords: Samarium diiodide, catalysis, amines, Aza-Michael reaction, carbon-nitrogen bond formation

Abstract: Samarium diiodide is an efficient Lewis acid type catalyst for the 1,4-addition of aromatic amines onto α,β- unsaturated N-benzoyl amides affording new β-amino amides. These reactions are compared with similar aza-Michael additions involving α,β-unsaturated-N-acyloxazolidinones.

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Reboule Irena, Bezzenine-Lafollee Sophie, Collin Jacqueline, Gil Richard and Martin Myriam, Samarium Diiodide Catalyzed Aza-Michael Reactions for the Formation of β-Amino Amides, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796255