Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media

Daniele      Biondini; Lucia      Brinchi; Raimondo      Germani; Laura      Goracci; Gianfranco      Savelli

doi:10.2174/157017810790533940

Abstract

Ionic liquid 1,3-dimethylimidazolium methanesulfonate was used to prepare α-amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.

Keywords: Ionic liquid, esterification, amino acids, nucleophilic substitution

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Letters in Organic Chemistry

Title: Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media

Volume: 7 Issue: 1

Author(s): Daniele Biondini, Lucia Brinchi, Raimondo Germani, Laura Goracci and Gianfranco Savelli

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Keywords: Ionic liquid, esterification, amino acids, nucleophilic substitution

Abstract: Ionic liquid 1,3-dimethylimidazolium methanesulfonate was used to prepare α-amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.

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Biondini Daniele, Brinchi Lucia, Germani Raimondo, Goracci Laura and Savelli Gianfranco, Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media, Letters in Organic Chemistry 2010; 7 (1) . https://dx.doi.org/10.2174/157017810790533940