Studies on the Pharmacokinetics of Methotrexate by Scintigraphic Monitoring of [99mTc]Pteridinic Derivatives Biodistribution

Title: Studies on the Pharmacokinetics of Methotrexate by Scintigraphic Monitoring of [99mTc]Pteridinic Derivatives Biodistribution

Volume: 7 Issue: 2

Author(s): R. G. Fumarel, P. Alber, A. Hurduc, N. Stafidov and M. L. Pascu

Affiliation:

Keywords: Methotrexate, Photosensitiser, Radioactive labelling, Radioactive chromatography, Gel filtration, Scintigraphy

Abstract: Methotrexate (MTX) use associated with optical irradiation of the malignant tumours requires knowledge of its intratumoral retention time. Radioactive Chromatography and absorption spectroscopy confirm synthesizing of 2,4 diamino 6-pertechnetate pterine that pursues MTX biodistribution. Sequential scintigraphy shows an intratumoral MTX retention time of one hour from systemic administration in bolus.

Cite this article as:

Fumarel G. R., Alber P., Hurduc A., Stafidov N. and Pascu L. M., Studies on the Pharmacokinetics of Methotrexate by Scintigraphic Monitoring of [99mTc]Pteridinic Derivatives Biodistribution, Letters in Drug Design & Discovery 2010; 7 (2) . https://dx.doi.org/10.2174/157018010790225859

DOI https://dx.doi.org/10.2174/157018010790225859	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X