Kinetic and Conformational Studies of Adenosine Deaminase Upon Interaction with Oxazepam and Lorazepam

A.   A.   Moosavi-Movahedi; H.   Sepassi   Tehrani; M.      Amanlou; M.   N.   Soltani Rad; G.   H.   Hakimelahi; F.   Y.   Tsai; A.   A.   Saboury; F.      Ahmad; A.      Khalafi-Nezhad; N.      Poursasan; A.      Sharifizadeh

doi:10.2174/092986610790226076

Abstract

Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

Keywords: Adenosine deaminase, oxazepam, lorazepam, kinetics, structures

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Protein & Peptide Letters

Title: Kinetic and Conformational Studies of Adenosine Deaminase Upon Interaction with Oxazepam and Lorazepam

Volume: 17 Issue: 2

Author(s): A. A. Moosavi-Movahedi, H. Sepassi Tehrani, M. Amanlou, M. N. Soltani Rad, G. H. Hakimelahi, F. Y. Tsai, A. A. Saboury, F. Ahmad, A. Khalafi-Nezhad, N. Poursasan and A. Sharifizadeh

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Keywords: Adenosine deaminase, oxazepam, lorazepam, kinetics, structures

Abstract: Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

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Moosavi-Movahedi A. A., Tehrani Sepassi H., Amanlou M., Soltani Rad N. M., Hakimelahi H. G., Tsai Y. F., Saboury A. A., Ahmad F., Khalafi-Nezhad A., Poursasan N. and Sharifizadeh A., Kinetic and Conformational Studies of Adenosine Deaminase Upon Interaction with Oxazepam and Lorazepam, Protein & Peptide Letters 2010; 17 (2) . https://dx.doi.org/10.2174/092986610790226076