Iron Trichloride Catalyzed One-Pot Synthesis of Substituted Oxazoles from Propargylic Acetates and Amides under Microwave Irradiation

Wen-Wen      Xu; Min      Lin; Yang      Huang; Li      Chen; Zhuang-Ping      Zhan

doi:10.2174/157017809790442970

Abstract

A rapid and efficient procedure under microwave irradiation, using silica gel-supported reagents for the synthesis of substitued oxazoles has been developed through iron trichloride catalyzed propargylation/cycloisomerization tandem reaction of propargylic acetates and amides.

Keywords: Iron trichloride, oxazole, microwave irradiation

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Letters in Organic Chemistry

Title: Iron Trichloride Catalyzed One-Pot Synthesis of Substituted Oxazoles from Propargylic Acetates and Amides under Microwave Irradiation

Volume: 6 Issue: 8

Author(s): Wen-Wen Xu, Min Lin, Yang Huang, Li Chen and Zhuang-Ping Zhan

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Keywords: Iron trichloride, oxazole, microwave irradiation

Abstract: A rapid and efficient procedure under microwave irradiation, using silica gel-supported reagents for the synthesis of substitued oxazoles has been developed through iron trichloride catalyzed propargylation/cycloisomerization tandem reaction of propargylic acetates and amides.

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Xu Wen-Wen, Lin Min, Huang Yang, Chen Li and Zhan Zhuang-Ping, Iron Trichloride Catalyzed One-Pot Synthesis of Substituted Oxazoles from Propargylic Acetates and Amides under Microwave Irradiation, Letters in Organic Chemistry 2009; 6 (8) . https://dx.doi.org/10.2174/157017809790442970