NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ

Jason      Lauer; Debarshi      Banerjee; Denton      Shanks; Huaien      Dai; Yu-Xi      Gong; Om      Prakash; Dolores      Takemoto

doi:10.2174/092986610789909485

Abstract

The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.

Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109

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Protein & Peptide Letters

Title: NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ

Volume: 17 Issue: 1

Author(s): Jason Lauer, Debarshi Banerjee, Denton Shanks, Huaien Dai, Yu-Xi Gong, Om Prakash and Dolores Takemoto

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Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109

Abstract: The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.

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Lauer Jason, Banerjee Debarshi, Shanks Denton, Dai Huaien, Gong Yu-Xi, Prakash Om and Takemoto Dolores, NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ, Protein & Peptide Letters 2010; 17 (1) . https://dx.doi.org/10.2174/092986610789909485