The Asymmetric Pictet – Spengler Reaction

Title: The Asymmetric Pictet – Spengler Reaction

Volume: 7 Issue: 3

Author(s): Michael Lorenz, Michael L. Van Linn and James M. Cook

Affiliation:

Keywords: Asymmetric Pictet, –, Spengler reaction, diastereoselective, enantioselective, indole alkaloids, organocatalysis, spiroindolenine

Abstract: Recent advances via internal and external asymmetric induction in the asymmetric Pictet – Spengler reaction employed in the synthesis of indole alkaloids are described. Mechanistic studies on the diastereoselectivity, important reaction intermediates, possible mechanisms of the cis to trans isomerization, as well as recent organocatalytic approaches have been highlighted.

Cite this article as:

Lorenz Michael, L. Van Linn Michael and M. Cook James, The Asymmetric Pictet – Spengler Reaction, Current Organic Synthesis 2010; 7 (3) . https://dx.doi.org/10.2174/157017910791163011