The Fink Blueprint for Hsp70/Hsc70 Molecular Chaperones

Stephan   N.   Witt

doi:10.2174/138920309789352047

Abstract

In a Nature article published in 1993, Anthony L. Fink and colleagues reported how Hsp70 chaperones use ATP binding in the presence of K+, rather than hydrolysis, to accelerate substrate release. As of the summer of 2008, his article had received 297 citations. I discuss here the influence Tonys iconic article has had on the chaperone field.

Keywords: Chaperone, heat shock protein, unfolded protein, ATPase

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