β -Lactamases- the Threat Renews

Title: β -Lactamases- the Threat Renews

Volume: 10 Issue: 5

Author(s): David M. Livermore

Affiliation:

Abstract: β-Lactamases are the greatest single source of resistance to β-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new β-lactam analogues are introduced but then select for new β-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM- 1 enzyme and modern oxymino cephalosporins by “extended-spectrum” β-lactamases. Tony Finks work contributed greatly to our understanding of the mechanisms and active site function of β-lactamases and this knowledge now informs the search for new β-lactams and β-lactamase inhibitors.

Cite this article as:

Livermore M. David, β -Lactamases- the Threat Renews, Current Protein & Peptide Science 2009; 10 (5) . https://dx.doi.org/10.2174/138920309789351994