Biocatalysis in the Preparation of the Statin Side Chain

Title: Biocatalysis in the Preparation of the Statin Side Chain

Volume: 6 Issue: 4

Author(s): Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva

Affiliation:

Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase

Abstract: Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

Cite this article as:

Liljeblad Arto, Kallinen Annukka and Kanerva T. Liisa, Biocatalysis in the Preparation of the Statin Side Chain, Current Organic Synthesis 2009; 6 (4) . https://dx.doi.org/10.2174/157017909789108738