Human Prion Protein Helices: Studying Their Stability by Molecular Dynamics Simulations (SUPPLEMENTARY MATERIAL)

Susan      Costantini; Angelo   M.   Facchiano

doi:10.2174/092986609789055313

Abstract

To study the intrinsic structural properties of three human prion helices and analyse their stability, we conducted molecular dynamics simulations, applied helix propensity predictions and evaluated the energetic contribution of the helical regions to the PrP protein stability. Our results suggest that three helices present different stability and the helix 2 results the least stable.

Keywords: Prion, helix stability, helix propensity, molecular dynamics, helical peptides

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Protein & Peptide Letters

Title: Human Prion Protein Helices: Studying Their Stability by Molecular Dynamics Simulations (SUPPLEMENTARY MATERIAL)

Volume: 16 Issue: 9

Author(s): Susan Costantini and Angelo M. Facchiano

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Keywords: Prion, helix stability, helix propensity, molecular dynamics, helical peptides

Abstract: To study the intrinsic structural properties of three human prion helices and analyse their stability, we conducted molecular dynamics simulations, applied helix propensity predictions and evaluated the energetic contribution of the helical regions to the PrP protein stability. Our results suggest that three helices present different stability and the helix 2 results the least stable.

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Costantini Susan and Facchiano M. Angelo, Human Prion Protein Helices: Studying Their Stability by Molecular Dynamics Simulations (SUPPLEMENTARY MATERIAL), Protein & Peptide Letters 2009; 16 (9) . https://dx.doi.org/10.2174/092986609789055313