Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target

Title: Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target

Volume: 9 Issue: 9

Author(s): A. Klettner and J. Roider

Affiliation:

Keywords: VEGF, ranibizumab, lucentis, AMD, pegaptanib, VEGF-trap

Abstract: The neutralization of VEGF is the current treatment of choice for age-related macular degeneration. Current approaches include anti-VEGF-antibodies and – Fab Fragments, aptamers, soluble receptors (Traps) and siRNA. The molecular properties of VEGF and its antagonists are reviewed and the pathways of action of these substances are discussed.

Cite this article as:

Klettner A. and Roider J., Treating Age-Related Macular Degeneration – Interaction of VEGF-Antagonists with their Target, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922665