Abstract
The structure of penicillazine has been revised on the basis of hydrolysis reaction. Its absolute stereochemistry has been confirmed by X-ray diffraction using copper radiation. Eight new penicillazine derivatives (1-8) were prepared and some of them showed higher levels of activity than penicillazine against α-glucosidase and Human DNA topoisomerase I.
Keywords: Penicillazine, derivatives, structure revision, biological activities, α-glucosidase, Human DNA topoisomerase I
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