1-Benzyl-1,2,3,4-tetrahydroisoquinoline Derivatives and Optically Pure Isomers as Novel Promising Multidrug Resistance (MDR) Reversing Agents

Title: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline Derivatives and Optically Pure Isomers as Novel Promising Multidrug Resistance (MDR) Reversing Agents

Volume: 6 Issue: 5

Author(s): Lingjing Xue, Minjie Sun, Tao Min, Can Zhang and Hongbin Sun

Affiliation:

Keywords: Tetrahydroisoquinoline, Optical pure isomers, Multidrug resistance, P-glycoprotein, Synthesis, Reversing agents

Abstract: A series of chiral compounds were designed and synthesized as novel multidrug resistance (MDR) modulators on the basis of tetrahydroisoquinolines to reverse cancerous MDR on K562 cells and K562/DOX cells by using the MTT assay. The treatment of K562/DOX cells with 9e, 10a and 10e led to increased intracellular accumulation and decreased efflux of doxorubicin. The pharmacological effects of these tetrahydroisoquinolines on P-glycoprotein (P-gp) mediated MDR were much stronger than that of positive control drug verapamil.

Cite this article as:

Xue Lingjing, Sun Minjie, Min Tao, Zhang Can and Sun Hongbin, 1-Benzyl-1,2,3,4-tetrahydroisoquinoline Derivatives and Optically Pure Isomers as Novel Promising Multidrug Resistance (MDR) Reversing Agents, Letters in Drug Design & Discovery 2009; 6 (5) . https://dx.doi.org/10.2174/1570180810906050387

DOI https://dx.doi.org/10.2174/1570180810906050387	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X