Antimicrobial Peptides and Viral Fusion Peptides : How Different They Are?

P.      Joanne; P.      Nicolas; C.      El Amri

doi:10.2174/092986609788681814

Abstract

Similarly to antimicrobial peptides (AMPs), viral fusion peptides (FPs) are membrane-active peptides. This minireview emphasizes the common properties of AMPs and FPs with a special focus on the intrinsic flexibility and structural adaptability of these peptides that are responsible for different mode of interaction with the membrane bilayers. The potential use of AMPs as multifunctional drugs with both antibacterial and antiviral properties is discussed.

Keywords: Antimicrobial peptides, Viral fusion peptides, Hydrophobicity, Structural plasticity, GXXXG motif, Membrane disruptive properties

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Protein & Peptide Letters

Title: Antimicrobial Peptides and Viral Fusion Peptides : How Different They Are?

Volume: 16 Issue: 7

Author(s): P. Joanne, P. Nicolas and C. El Amri

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Keywords: Antimicrobial peptides, Viral fusion peptides, Hydrophobicity, Structural plasticity, GXXXG motif, Membrane disruptive properties

Abstract: Similarly to antimicrobial peptides (AMPs), viral fusion peptides (FPs) are membrane-active peptides. This minireview emphasizes the common properties of AMPs and FPs with a special focus on the intrinsic flexibility and structural adaptability of these peptides that are responsible for different mode of interaction with the membrane bilayers. The potential use of AMPs as multifunctional drugs with both antibacterial and antiviral properties is discussed.

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Joanne P., Nicolas P. and El Amri C., Antimicrobial Peptides and Viral Fusion Peptides : How Different They Are?, Protein & Peptide Letters 2009; 16 (7) . https://dx.doi.org/10.2174/092986609788681814