Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest

Title: Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest

Volume: 9 Issue: 8

Author(s): K. Mazak, S. Hosztafi, A. Racz and B. Noszal

Affiliation:

Keywords: Morphine, pharmacokinetic properties, physicochemical profiling, acid/base properties, lipophilicity, solubility, permeability, stability

Abstract: A concise account of the physicochemical properties of morphine and its derivatives of therapeutic interest is provided. Such properties include macroscopic and microscopic acid/base parameters, lipophilicity, solubility, permeability that all influence the fate of drugs in the body. The dependence of these parameters on pH is discussed and subsequent implications in drug administration and formulation are presented.

Cite this article as:

Mazak K., Hosztafi S., Racz A. and Noszal B., Structural and Physicochemical Profiling of Morphine and Related Compounds of Therapeutic Interest, Mini-Reviews in Medicinal Chemistry 2009; 9 (8) . https://dx.doi.org/10.2174/138955709788681555