Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist

Title: Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist

Volume: 16 Issue: 6

Author(s): Caroline Brunetto de Farias, Laura Stertz, Rodrigo Cruz Lima, Flavio Kapczinski, Gilberto Schwartsmann and Rafael Roesler

Affiliation:

Keywords: Gastrin-releasing peptide receptor, RC-3095, nerve growth factor, colon cancer

Abstract: The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10 , 10 , or 1 μM) decreases nerve growth factor (NGF) secretion measured by enzymelinked immunosorbent assay (ELISA) in HT-29 human colon carcinoma cells. The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative effects in cancer cells.

Cite this article as:

de Farias Brunetto Caroline, Stertz Laura, Lima Cruz Rodrigo, Kapczinski Flavio, Schwartsmann Gilberto and Roesler Rafael, Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490177