Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors

Nikolaos      Athinaios; Athanasios      Kazantzis; Kerstin      Putzker; Joe      Lewis; Emmanuel   N.   Pitsinos

doi:10.2174/157017809788489891

Abstract

Employing a flexible synthetic strategy towards laurenditerpenol, two analogues featuring the 7- oxabicyclo[2.2.1]heptane ring system present in the natural product have been prepared and their ability to inhibit HIF-1 activation has been evaluated. Their weak activity indicates the importance of the cyclohexenol part of the prototype.

Keywords: Furan, Diels-Alder reaction, Olefin cross-metathesis, Natural products

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Letters in Organic Chemistry

Title: Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors

Volume: 6 Issue: 4

Author(s): Nikolaos Athinaios, Athanasios Kazantzis, Kerstin Putzker, Joe Lewis and Emmanuel N. Pitsinos

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Keywords: Furan, Diels-Alder reaction, Olefin cross-metathesis, Natural products

Abstract: Employing a flexible synthetic strategy towards laurenditerpenol, two analogues featuring the 7- oxabicyclo[2.2.1]heptane ring system present in the natural product have been prepared and their ability to inhibit HIF-1 activation has been evaluated. Their weak activity indicates the importance of the cyclohexenol part of the prototype.

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Athinaios Nikolaos, Kazantzis Athanasios, Putzker Kerstin, Lewis Joe and Pitsinos N. Emmanuel, Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489891