D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain

Title: D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain

Volume: 9 Issue: 7

Author(s): R. Sethuraman, T. L. Lee and S. Tachibana

Affiliation:

Keywords: D-Serine, NMDA receptors, CNS diseases, chronic pain, serine racemase, D-amino acid oxidase, amino acid transporters

Abstract: D-Serine, an endogenous modulator of NMDA receptors has been shown to play a vital role in many neuropsychiatric functions such as learning, memory, nociception and implicated in pathological conditions like schizophrenia and Alzheimers disease. We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism.

Cite this article as:

Sethuraman R., Lee L. T. and Tachibana S., D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain, Mini-Reviews in Medicinal Chemistry 2009; 9 (7) . https://dx.doi.org/10.2174/138955709788452630