New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

Title: New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

Volume: 9 Issue: 7

Author(s): Alessandro Pezzini, Elisabetta Del Zotto, Irene Volonghi, Alessia Giossi, Paolo Costa and Alessandro Padovani

Affiliation:

Keywords: HMG-CoA reductase inhibitors, stroke, pleiotropic effects

Abstract: There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - “statins” - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - “pleiotropic” - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.

Cite this article as:

Pezzini Alessandro, Del Zotto Elisabetta, Volonghi Irene, Giossi Alessia, Costa Paolo and Padovani Alessandro, New Insights into the Pleiotropic Effects of Statins for Stroke Prevention, Mini-Reviews in Medicinal Chemistry 2009; 9 (7) . https://dx.doi.org/10.2174/138955709788452658