Abstract
An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a one-pot three-component cyclocondensation reaction of an aromatic aldehyde, β-ketoester, and urea or thiourea under solvent-free conditions using triethylamine (Et3N) as catalyst for the Biginelli reaction.
Keywords: Triethylamine, Bronsted bases, multicomponent reaction, 3,4-dihydropyrimidin-2(1H)-ones/thiones, Biginelli reaction, one-pot condensation
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