Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body

Title: Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body

Volume: 9 Issue: 5

Author(s): H. Kalasz, J. Furesz and K. Tekes

Affiliation:

Keywords: Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203

Abstract: A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.

Cite this article as:

Kalasz H., Furesz J. and Tekes K., Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167565