Gastrulation Defective Protease Interacts with Anionic Components of the Drosophila Ovary Extracellular Matrix

Sangeetha      Sukumari-Ramesh; Ellen   K.   LeMosy

doi:10.2174/092986609787848135

Abstract

The Drosophila proteases Gastrulation Defective and Snake function in embryonic polarity establishment and bind heparin, a surrogate for anionic species present in the extracellular matrix. Here we demonstrate binding of GD, but not Snake, to anionic species that appear to be tightly associated with a highly purified eggshell matrix.

Keywords: Gastrulation Defective, Snake, Pipe, embryonic polarity, serine protease cascade, Drosophila

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Protein & Peptide Letters

Title: Gastrulation Defective Protease Interacts with Anionic Components of the Drosophila Ovary Extracellular Matrix

Volume: 16 Issue: 4

Author(s): Sangeetha Sukumari-Ramesh and Ellen K. LeMosy

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Keywords: Gastrulation Defective, Snake, Pipe, embryonic polarity, serine protease cascade, Drosophila

Abstract: The Drosophila proteases Gastrulation Defective and Snake function in embryonic polarity establishment and bind heparin, a surrogate for anionic species present in the extracellular matrix. Here we demonstrate binding of GD, but not Snake, to anionic species that appear to be tightly associated with a highly purified eggshell matrix.

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Sukumari-Ramesh Sangeetha and LeMosy K. Ellen, Gastrulation Defective Protease Interacts with Anionic Components of the Drosophila Ovary Extracellular Matrix, Protein & Peptide Letters 2009; 16 (4) . https://dx.doi.org/10.2174/092986609787848135