Design and Synthesis of Substrates for Model Ribosomal Reactions

Stanislav   G.   Bayryamov; Nikolay   G.   Vassilev; Miroslav   A.   Rangelov; Aneta   P.   Mladjova; Dimiter   D.   Petkov

doi:10.2174/092986609787848009

Abstract

2/3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-Ado (1) and its deoxy analog: 3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-2- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.

Keywords: Design, peptide synthesis, nucleoside synthesis, ribosome catalysis

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Protein & Peptide Letters

Title: Design and Synthesis of Substrates for Model Ribosomal Reactions

Volume: 16 Issue: 4

Author(s): Stanislav G. Bayryamov, Nikolay G. Vassilev, Miroslav A. Rangelov, Aneta P. Mladjova and Dimiter D. Petkov

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Keywords: Design, peptide synthesis, nucleoside synthesis, ribosome catalysis

Abstract: 2/3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-Ado (1) and its deoxy analog: 3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-2- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.

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Bayryamov G. Stanislav, Vassilev G. Nikolay, Rangelov A. Miroslav, Mladjova P. Aneta and Petkov D. Dimiter, Design and Synthesis of Substrates for Model Ribosomal Reactions, Protein & Peptide Letters 2009; 16 (4) . https://dx.doi.org/10.2174/092986609787848009