EQCM Biosensors Based on DNA Aptamers and Antibodies for Rapid Detection of Prions

T.      Hianik; A.      Porfireva; I.      Grman; G.      Evtugyn

doi:10.2174/092986609787848090

Abstract

Novel affinity biosensors for detecting cellular prions, PrPC, based on DNA aptamers and antibodies immobilized onto the carbon nanotubes have been designed and compared in accordance with their binding ability and analytical performance. The biosensors allowed us to detect PrPC with the limits of detection of 20 to 50 pM.

Keywords: Prion proteins, DNA aptamers, antibodies, biosensor, multiwalled carbon nanotubes, electrochemical quartz crystal microbalance

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Protein & Peptide Letters

Title: EQCM Biosensors Based on DNA Aptamers and Antibodies for Rapid Detection of Prions

Volume: 16 Issue: 4

Author(s): T. Hianik, A. Porfireva, I. Grman and G. Evtugyn

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Keywords: Prion proteins, DNA aptamers, antibodies, biosensor, multiwalled carbon nanotubes, electrochemical quartz crystal microbalance

Abstract: Novel affinity biosensors for detecting cellular prions, PrPC, based on DNA aptamers and antibodies immobilized onto the carbon nanotubes have been designed and compared in accordance with their binding ability and analytical performance. The biosensors allowed us to detect PrPC with the limits of detection of 20 to 50 pM.

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Hianik T., Porfireva A., Grman I. and Evtugyn G., EQCM Biosensors Based on DNA Aptamers and Antibodies for Rapid Detection of Prions, Protein & Peptide Letters 2009; 16 (4) . https://dx.doi.org/10.2174/092986609787848090