Capsid (CA) Protein as a Novel Drug Target: Recent Progress in the Research of HIV-1 CA Inhibitors

Title: Capsid (CA) Protein as a Novel Drug Target: Recent Progress in the Research of HIV-1 CA Inhibitors

Volume: 9 Issue: 4

Author(s): Jiyan Zhang, Xinyong Liu and Erik De Clercq

Affiliation:

Keywords: HIV-1, AIDS, capsid inhibitor, antiviral agents, CA-N, CA-C, mutation

Abstract: The capsid (CA) protein is the major structural component of HIV-1 and plays a key role in the regulation of viral life cycle. Inhibition of CA will affect the viral assembly and budding processes, causing decreased viral infectivity. This review describes the structure and function of the HIV-1 CA and latest progress in the discovery of HIV-1 CA inhibitors.

Cite this article as:

Zhang Jiyan, Liu Xinyong and De Clercq Erik, Capsid (CA) Protein as a Novel Drug Target: Recent Progress in the Research of HIV-1 CA Inhibitors, Mini-Reviews in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/138955709787847958