Design and Synthesis of New Cap Analogs Containing 2-OH Modifications on Both Guanosine and m7Guanosine Moieties

Anilkumar   R.   Kore; Muthian      Shanmugasundaram

doi:10.2174/157017809787582852

Abstract

Synthesis of new cap analogs containing 2-OH modifications on both guanosine and m7guanosine moieties such as m2 7,2OG[5]ppp[5]m2OG and 2-OH modifications on both m7guanosine moieties such as m2 7,2OG[5]ppp[5] m2 7,2OG are reported. Structures were confirmed by 1H and 31P NMR and mass spectral data.

Keywords: Guanosine, phosphorylation, methylation, modified cap analogs

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Letters in Organic Chemistry

Title: Design and Synthesis of New Cap Analogs Containing 2-OH Modifications on Both Guanosine and m7Guanosine Moieties

Volume: 6 Issue: 2

Author(s): Anilkumar R. Kore and Muthian Shanmugasundaram

Affiliation:

Keywords: Guanosine, phosphorylation, methylation, modified cap analogs

Abstract: Synthesis of new cap analogs containing 2-OH modifications on both guanosine and m7guanosine moieties such as m2 7,2OG[5]ppp[5]m2OG and 2-OH modifications on both m7guanosine moieties such as m2 7,2OG[5]ppp[5] m2 7,2OG are reported. Structures were confirmed by 1H and 31P NMR and mass spectral data.

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Kore R. Anilkumar and Shanmugasundaram Muthian, Design and Synthesis of New Cap Analogs Containing 2-OH Modifications on Both Guanosine and m7Guanosine Moieties, Letters in Organic Chemistry 2009; 6 (2) . https://dx.doi.org/10.2174/157017809787582852