Physiological and Pathophysiological Functions of SIRT1

Title: Physiological and Pathophysiological Functions of SIRT1

Volume: 9 Issue: 3

Author(s): M. Wojcik, K. Mac-Marcjanek and L. A. Wozniak

Affiliation:

Keywords: FOXO factors, NAD+-dependent deacetylase, p53, resveratrol, Sir2, SIRT1

Abstract: The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.

Cite this article as:

Wojcik M., Mac-Marcjanek K. and Wozniak A. L., Physiological and Pathophysiological Functions of SIRT1, Mini-Reviews in Medicinal Chemistry 2009; 9 (3) . https://dx.doi.org/10.2174/1389557510909030386