Stabilities of 67Ga- and 111In-Labeled Transferrin In Vitro

Yosuke      Ohtake; Akiko      Maruko; Yoshikazu      Kuwahara; Manabu      Fukumoto; Yasuhito      Ohkubo

doi:10.2174/092986609787316298

Abstract

We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111In- DTPA-Tf was also the most stable radiolabeled transferrin in the blood.

Keywords: Transferrin, radiolabeling, DTPA, 67Ga, 111In

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Protein & Peptide Letters

Title: Stabilities of 67Ga- and 111In-Labeled Transferrin In Vitro

Volume: 16 Issue: 2

Author(s): Yosuke Ohtake, Akiko Maruko, Yoshikazu Kuwahara, Manabu Fukumoto and Yasuhito Ohkubo

Affiliation:

Keywords: Transferrin, radiolabeling, DTPA, 67Ga, 111In

Abstract: We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111In- DTPA-Tf was also the most stable radiolabeled transferrin in the blood.

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Ohtake Yosuke, Maruko Akiko, Kuwahara Yoshikazu, Fukumoto Manabu and Ohkubo Yasuhito, Stabilities of 67Ga- and 111In-Labeled Transferrin In Vitro, Protein & Peptide Letters 2009; 16 (2) . https://dx.doi.org/10.2174/092986609787316298