Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells

Title: Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells

Volume: 16 Issue: 1

Author(s): Noriyuki Shiraishi, Yoko Inai and Yoshito Ihara

Affiliation:

Keywords: Prion protein, PrP-(23-98), aggregates, cytotoxicity, apoptosis, PrP-deficient cell line

Abstract: Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur.

Cite this article as:

Shiraishi Noriyuki, Inai Yoko and Ihara Yoshito, Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells, Protein & Peptide Letters 2009; 16 (1) . https://dx.doi.org/10.2174/092986609787049475