New Solid-Phase Approach to Synthesize a Hyacinthacine Core Using the L-Proline as a Building Block

Monica   O.   Duarte; Guilherme      Stedele; Mariane      Pazinatto; Eduardo   R.   de Oliveira; Vera   L.   Eifler-Lima

doi:10.2174/157017809787003241

Abstract

A new solid-phase synthesis of pyrrolizidine nucleus related to hyacinthacine core using L-proline as the starting material is reported. The final step is a new approach with a cyclization-cleave strategy, which releases the product from the resin in good yields under Baylis-Hillman conditions.

Keywords: Hyacinthacine core, solid-phase organic synthesis, L-Proline, enaminoester, Baylis-Hillman reaction

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Letters in Organic Chemistry

Title: New Solid-Phase Approach to Synthesize a Hyacinthacine Core Using the L-Proline as a Building Block

Volume: 6 Issue: 1

Author(s): Monica O. Duarte, Guilherme Stedele, Mariane Pazinatto, Eduardo R. de Oliveira and Vera L. Eifler-Lima

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Keywords: Hyacinthacine core, solid-phase organic synthesis, L-Proline, enaminoester, Baylis-Hillman reaction

Abstract: A new solid-phase synthesis of pyrrolizidine nucleus related to hyacinthacine core using L-proline as the starting material is reported. The final step is a new approach with a cyclization-cleave strategy, which releases the product from the resin in good yields under Baylis-Hillman conditions.

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Duarte O. Monica, Stedele Guilherme, Pazinatto Mariane, de Oliveira R. Eduardo and Eifler-Lima L. Vera, New Solid-Phase Approach to Synthesize a Hyacinthacine Core Using the L-Proline as a Building Block, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003241